Alveolar macrophage proteinase/antiproteinase expression and lung function/emphysema
نویسندگان
چکیده
1) UBC James Hogg Research Centre, Institute for Heart + Lung Health, St. Paul’s Hospital, Vancouver, Canada. 2) Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases and Oncology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan. 3) Division of Respiratory Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, Canada. 4) Department of Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, Canada. 5) Department of Pathology, Vancouver General Hospital, University of British Columbia, Vancouver, Canada. 6) Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, Canada. 7) Department of Medicine, Division of Respiratory Medicine, University of British Columbia, Vancouver, Canada.
منابع مشابه
Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema.
Alveolar macrophages play an important role in chronic obstructive pulmonary disease via production of matrix metalloproteinases (MMPs) and cathepsins as well as their inhibitors, tissue inhibitors of metalloproteinases and cystatin C. We hypothesised that expression levels of these molecules by alveolar macrophages at baseline and after stimulation would be influenced by genotype and associate...
متن کاملComparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors.
Elastin is an extracellular matrix protein critical to the normal structure and function of human lung. Recently reported data indicate that live human alveolar macrophages can degrade purified elastin in vitro. In this study, we directly compared the elastolytic activity of alveolar macrophages with that of human neutrophils. In the absence of proteinase inhibitors, human neutrophils degrade m...
متن کاملChronic obstructive pulmonary disease - part 2: pathology and biochemistry of emphysema.
The pathology and pathogenesis of emphysema are reviewed, with particular reference to the proteinase-antiproteinase hypothesis.
متن کاملA distinctive alveolar macrophage activation state induced by cigarette smoking.
RATIONALE Macrophages are believed to play a central role in emphysema based largely on data from mouse models. However, the relevance of these models to smoking-related lung disease in humans is uncertain. OBJECTIVES We sought to comprehensively characterize the effects of smoking on gene expression in human alveolar macrophages and to compare these with effects seen in transgenic mouse mode...
متن کاملMacrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways
Reactive oxygen species (ROS) participate in the pathogenesis of emphysema. Among ROS-producing enzymes, NOX NADPH oxidases are thought to be responsible for tissue injury associated with several lung pathologies. To determine whether NOX2 and/or NOX1 participate in the development of emphysema, their expression patterns were first studied by immunohistochemistry in the lungs of emphysematous p...
متن کامل